Plant : – It is a place where the 5 M’s like money, material; man, method and machine are brought together for the manufacturing of the products. Pilot Plant : – It is the part of the pharmaceutical industry where a lab scale formula is transformed into a viable product by development of liable and practical procedure of manufacture. Scale-up : – The art for designing of prototype using the data obtained from the pilot plant model. Definitions R & D Production Pilot Plant. Objectives of Pilot Plant “Find mistakes on small scale and make profit on large scale.” To produce physically and chemically stable therapeutic dosage forms. Review of the processing equipment. Guidelines for productions and process control. Evaluation and validation for process and equipment’s. To identify the critical features of the process. To provide master manufacturing formula. To try the process on a model of proposed plant before committing large sum of money on a production unit. Examination of the f