Kerone

  Solid amorphous dispersions are frequently used to improve the solubility and, thus, the bioavailability of poorly soluble active pharmaceutical ingredients (APIs).   Spray-drying , a well-characterized pharmaceutical unit operation is ideally suited to producing solid amorphous dispersions due to its rapid drying kinetics. This paper describes a novel flowchart methodology based on fundamental engineering models and state-of-the-art process characterization techniques that ensure that spray-drying process development and scale-up are efficient and require minimal time and API. This methodology offers substantive advantages over traditional process-development methods, which are often empirical and require large quantities of API and long development times. The methodology is used from early formulation-screening activities (involving milligrams of API) through process development and scale-up for early clinical supplies (involving kilograms of API) to commercial manufacturing (invol

  Kerone has been familiar with the development of rice mills/plants from last 47 years. We are the right partner from a mill with an hourly capability of 2,000 kilogram to the totally automated giant mill. Our clients can avail from us an excellent range of   Rice Processing Plant , which is made using latest technology. Widely used for making finest quality rice, these plants are easily installable and thus deliver best results. These plans are highly appreciated for their features like reliable operations and less maintenance. We at Kerone Design and Manufacture   Customized Rice Mills/Plants   in many specifications. Rice is the world’s largest food crop and in many countries of the world rice is the most important staple food. Due to the constantly growing world population the demand for rice continues to increase. It has become necessary to meet the demand of the world’s current population growth rate, and the least costly means for achieving this aim is to increase rice producti